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dragonlobster

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Lectins: The Plant Defense System - MD Gundry [Lecture]

Dr. Steven Gundry, renowned heart surgeon and functional medicine pioneer, as he explores the science and clinical application of lectins, aquaporins, and intestinal permeability using Vibrant Wellness testing. With decades of experience and thousands of patient cases, Dr. Gundry breaks down the mechanisms behind food-triggered autoimmunity, leaky gut, and how precision testing can uncover hidden drivers of chronic disease. ::: spoiler summerizer Background and lectin model Dr. Gundry’s path into lectins began through heart-transplant and xeno-transplant work, where Neu5Ac, Neu5Gc, and wheat germ agglutinin made sugar-binding proteins clinically important. Lectins are sticky proteins in plants and animals that bind specific sugar molecules on blood vessels, gut lining, red blood cells, joints, and nerve junctions. Plant lectins function mainly as a defense system against predators, with humans functioning as large plant predators from the plant’s perspective. Gluten belongs within the prolamine lectin class and differs from other lectins by source, size, and behavior. Where lectins come from Legumes, grains, and nightshades are the major dietary sources, with peanut handled as a legume and nightshades including peppers, tomatoes, potatoes, goji berries, tomatillos, and tobacco. Many lectins are located in the sprouting part of seeds and in seed hulls, with wheat germ agglutinin in wheat germ and hull-associated lectins in wheat, rye, and barley. Grains such as millet, sorghum, and fonio differ from wheat, rye, and barley because they lack the same hull problem. Lectins resist digestion and ordinary cooking, so food preparation matters more than casual cooking advice. Gut-barrier and immune mechanism Fasano’s zonulin work explains how lectins bind intestinal epithelial cells, loosen tight junctions, create leaky gut, and allow immune activation. Molecular mimicry explains how antibodies against dietary lectins can cross-react with human tissue and drive autoimmune patterns. Wheat germ agglutinin and aquaporins are small lectins that can cross the gut barrier even without classic leaky gut. Modern lectin sensitivity links to microbiome disruption from antibiotics, glyphosate exposure, and loss of older practices such as soaking and fermentation. Aquaporins and difficult autoimmune cases Aquaporins are water-channel lectins shared by plants and humans, including human AQP4 in the gut, blood-brain barrier, and central nervous system. Food aquaporins in corn, spinach, potatoes, tomatoes, soybeans, bell peppers, and tobacco have similarity to human aquaporins. Food aquaporin antibodies are a possible route to neuroautoimmunity, leaky brain, myelin attack, neuropathy, MS-like patterns, brain fog, and Parkinson’s-like diagnoses. Spinach became a recurring concern after it showed up repeatedly in difficult autoimmune and leaky-gut cases that otherwise followed the program. Testing and clinical workflow The Lectin Zoomer is used to find IgG and IgA reactions to lectins from barley, bell pepper, chickpea, corn, cucumber, lentils, lima beans, mung beans, peas, peanuts, potatoes, rice, rye, soybeans, tomato, and kidney beans. A positive result is evidence that the lectin crossed the gut wall and met the systemic immune system; a negative result is not permission to eat that food freely. Aquaporin testing covers bell pepper, corn, potato, soybean, spinach, tobacco, and tomato, and positive foods are removed while markers are retested over time. Initial testing uses broad autoimmune and gut-related markers, including celiac HLA gluten profiling, ANA, rheumatoid factor, anti-CCP3, ENA, Wheat Zoomer, food sensitivity panels, and neuro panels when needed. Retesting occurs every three months, with positive foods removed until leaky-gut markers, wheat-component IgG/IgA, and autoimmune markers improve. The AHA abstract shows that nine out of ten autoimmune patients with leaky gut resolved leaky gut within a year after lectin-containing gluten-free foods were removed. Foods are reintroduced one at a time after markers clear, then Wheat Zoomer and autoimmune profiles are retested if symptoms stay quiet. Preparation, exposures, and gut repair Soaking and pressure cooking are used for beans because lectins leach into soaking water and pressure cooking reduces red-kidney-bean hemagglutinin activity. Sprouting is not relied on because lectins are located in the sprouting seed and sprouted grains are worse for vulnerable autoimmune patients. Glyphosate and antibiotics are major disruptors of the microbiome that weaken traditional tolerance to lectin-containing foods. Gut-repair compounds include N-acetylglucosamine, marshmallow, prebiotics, spore-forming bacteria, and butyrate because colon cells depend heavily on butyrate for energy and barrier function. Dried blood spot collection is used when needed because the platform is the same and only the collection method changes. Patients do not need to eat gluten or other avoided foods before testing, because long-term avoidance can still leave strong antibody findings. References [00:00] The Plant Paradox — https://www.harpercollins.com/products/the-plant-paradox-steven-r-gundry-md [01:00] The Longevity Paradox — https://www.harpercollins.com/products/the-longevity-paradox-steven-r-gundry-md [02:00] Potential deleterious role of anti-Neu5Gc antibodies in xenotransplantation — https://doi.org/10.1111/xen.12142 [03:00] Interaction of Wheat Germ Agglutinin With Sialic Acid — https://doi.org/10.1021/bi00591a038 [05:00] Karl Landsteiner – Facts — https://www.nobelprize.org/prizes/medicine/1930/landsteiner/facts/ [08:00] ABO blood group association and COVID-19. COVID-19 susceptibility and severity: a review — https://doi.org/10.1016/j.htct.2021.07.006 [14:00] Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3 — https://doi.org/10.1053/j.gastro.2008.03.023 [15:00] Modulation of immune function by dietary lectins in rheumatoid arthritis — https://doi.org/10.1017/S0007114500000271 [15:00] Reaction of Lectin-Specific Antibody with Human Tissue: Possible Contributions to Autoimmunity — https://doi.org/10.1155/2020/1438957 [16:00] Zonulin and its regulation of intestinal barrier function: the biological door to inflammation, autoimmunity, and cancer — https://doi.org/10.1152/physrev.00003.2008 [16:00] All disease begins in the (leaky) gut: role of zonulin-mediated gut permeability in the pathogenesis of some chronic inflammatory diseases — https://doi.org/10.12688/f1000research.20510.1 [20:00] Aquaporin 4 molecular mimicry and implications for neuromyelitis optica — https://doi.org/10.1016/j.jneuroim.2013.04.015 [23:00] Detection of Antibodies against Human and Plant Aquaporins in Patients with Multiple Sclerosis — https://doi.org/10.1155/2015/905208 [23:00] Plant and human aquaporins: pathogenesis from gut to brain — https://doi.org/10.1007/s12026-018-9046-z [24:00] Aquaporins: Unexpected actors in autoimmune diseases — https://doi.org/10.1016/j.autrev.2022.103131 [27:00] Effect of Heat Processing on Hemagglutinin Activity in Red Kidney Beans — https://doi.org/10.1111/j.1365-2621.1983.tb14831.x [29:00] Detection of IgE, IgG, IgA and IgM antibodies against raw and processed food antigens — https://doi.org/10.1186/1743-7075-6-22 [33:00] Abstract P219: The Vast Majority of People Who Eat “Gluten Free” for IBS, Celiac, or Autoimmune Disease Have Markers of Leaky Gut That Resolve When “Gluten Free” Foods Containing Lectins, Like Corn, Other Grains, Beans, and Nightshades are Removed From Their Diet — https://doi.org/10.1161/circ.141.suppl_1.P219 [43:00] Does Glyphosate Affect the Human Microbiota? — https://doi.org/10.3390/life12050707 [49:00] Butyrate Enhances the Intestinal Barrier by Facilitating Tight Junction Assembly via Activation of AMP-Activated Protein Kinase in Caco-2 Cell Monolayers — https://doi.org/10.3945/jn.109.104638 [51:00] The Energy Paradox — https://www.harpercollins.com/products/the-energy-paradox-steven-r-gundry-md :::

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SillyGooseQuacked

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Why are space shuttles always rockets, and take off straight upward?

Pretty good summary. I’ll add a couple corrections: This usually involves liquid oxygen. That’s heavy and under pressure The critical point of oxygen is below room temperature, meaning it is not possible to keep oxygen liquid using pressure alone. For rockets, liquid oxygen is typically loaded within hours or minutes prior to launch, before it has a chance to warm up and boil off. winning solution that could escape earth’s gravity well was the Falcon 9. A multi-stage rocket with different fuels for different stages Falcon 9 is a two-stage rocket, but it uses the same propellants (kerosene and liquid oxygen) on both stages. Also, I’m not sure if I would call the Falcon 9 the winning solution, just the “winningest” solution so far. SpaceX’s Starship, Stoke Space’s Nova, and any of the upcoming Falcon 9 clones have the potential to improve on the Falcon 9 design or solve the challenge of reusability in slightly different ways.

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goatmeal

“The list of things I used to be is longer than the list of things I am. Excommunicated atheist and an expatriate. Living for the small chance that somone night take a chance on an underrated writer overrated rapper, undecided major on an unrelated matter” Dessa from Doomtrree

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iljarogoff

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US F-35 readiness is falling as only 25% fully mission capable

One of the more pointed findings in the report is the concerns over the effectiveness of contractor incentive structures. Since 2020, the Pentagon has paid hundreds of millions of dollars in incentive fees intended to encourage improvements in aircraft readiness. However, GAO found that these incentives did not achieve their intended effect. The watchdog found that contractor performance thresholds often did not align with the readiness requirements established by the military services. As a result, contractors were able to qualify for incentive payments even when aircraft availability remained below desired levels.

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AI Economics for Dummies

As AI companies get ready to go public and we get a deeper look at their inner workings, it’s only natural to have questions about their finances, like “Do they make money?” and “How?” Here are a few examples to help the average layperson understand the business side of AI.

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Is this Chinese propaganda?

This is an appeal to forgive literal convicted terrorists that came up in my social media feed. Is this China redirecting the “free east turkistan” wave to show people “east turkistan” is a terrorist movement or are the CIA/NGO trolls just that out of touch with reality? The fact that the image includes the aftermath of their terrorist bombing makes me think this is China, and its really clever.

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Hunger Strikers in Adelanto ICE Jail Moved to Solitary After Meeting Congressmen

Last Monday, California Reps. Judy Chu, Jimmy Gomez, and Pete Aguilar visited Adelanto Immigration and Customs Enforcement (ICE) Processing Center as the hunger strike in the immigration jail entered its second week. The Democrats met with three of the hunger strikers, who gave them a petition, signed by some 150 people inside the facility, speaking of inhumane conditions inside the jail and degrading treatment by staff. The Adelanto ICE jail is run by private prison company GEO Group. The next day, GEO Group staff entered a unit “in riot gear holding pepper spray, tear gas canisters and zip ties,” and removed two of the people who had met with congressional staff the day before. And on Wednesday, they removed the third person, according to other detainees. Archived at https://web.archive.org/web/20260612121142/https://truthout.org/articles/hunger-strikers-in-adelanto-ice-jail-moved-to-solitary-after-meeting-congressmen/

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How Western Media Normalizes Israel's Ethnic Cleansing in Lebanon | Common Dreams

While the October 2024 embed was one of the more preposterous embodiments of Western corporate media’s special relationship with Israel, outlets continue to do a fine job of sanitizing Israeli brutality even when their reporters are not physically viewing the region from inside an Israeli armored vehicle. Since March of this year, Israel has killed at least 3,613 people in Lebanon and displaced 1.2 million, obliterating entire villages and otherwise expanding the ecocidal policy honed in the Gaza Strip. There has been no remotely comparable destruction on the Israeli side, and a recent Reuters article (5/31/26) that had attempted to suggest some symmetry now comes with the preface: “This May 31 story has been corrected to remove a reference to tens of thousands of Israelis being displaced by Hezbollah fire, in paragraph 3.” Like in Gaza, where genocide proceeds apace in spite of a declared ceasefire (FAIR.org, 10/21/25), the media tend to report “ceasefires” in Lebanon without caring to highlight the fact that it’s not a ceasefire when Israel is still pummeling the country and massacring people, all the while setting the stage for a massive land grab with its creeping so-called “evacuation orders.” … As Battah remarked to me, the media’s acceptance and deployment of such arbitrary vocabulary creates “artificial structures” and a sense of orderliness, when in reality “there’s no yellow lines, there’s no yellow, there’s no colors—these are just illegal invasions.” And because media are committed to sanitizing Israel’s behavior rather than questioning it, “colonization becomes normalized.” The eagerness of journalists to do Israel’s bidding is all the more confounding given that Israel is currently the No. 1 killer of journalists in the world. A recent Associated Press article (5/29/26), for example, reduced the pulverization of Lebanon to simply “ongoing fighting in southern Lebanon between Israeli troops and Hezbollah fighters.”

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Department Of Justice Approves Paramount Acquiring WBD

The Department of Justice has approved the Paramount acquisition of Warner Bros Discovery (WBD). There were antitrust concerns over the deal, and it could still face legal challenges from state attorneys general. The deal is valued at roughly $110 billion and is on track to be completed in September. The proposed merger has already received WBD shareholder approval. According to Politico, “After an extensive review, DOJ officials determined the transaction did not pose a threat to competition and declined to challenge it, said the people, who were granted anonymity to discuss sensitive matters. The department approved the merger without requiring any divestitures, behavioral remedies or concessions, according to one of the people.” All Elite Wrestling has a media rights deal with WBD through the end of 2027, with an option for 2028. Once the deal goes through, it is expected that Paramount streaming service Paramount+ and WBD service HBO Max will combine into one streaming platform. AEW television and pay-per-views stream on HBO Max, though it’s too early to know where AEW will land once the deal officially goes through and things are settled. I don’t remember the full context, but I recently saw someone from the Paramount side say that they don’t work for the UFC, the UFC works for them as far as exclusivity is concerned. Hopefully that means AEW can stay with their networks the next time their deal is up.

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Mama and baby

Found an adorable pair. Baby is under mom in the first pic but I got one of them both escaping my gaze.

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machine consciousness is just sciousness

I can’t define consciousness but I am not spiritual in any way and I beleive it arises from some physical process. If a computer can be conscious it would need to have an analogous process somewhere in it’s hardware. This would mean that consciouness would not be limited to LLMs, and the mathematical process in, for example, excel, could also be argued to be consciousness. Does that make sense?

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Dragonborn3810

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"If you can't afford to tip 40%, then don't eat out"

but I didn’t seek good service. I sought a basic level of service expected of someone doing their job. I don’t need service good enough to justify a $20 tip when I go out for wings and two beers and take up literally five minutes of the server’s time fuck tipping culture, pay your employees. wait staff aren’t special. you better be tipping retail associates at least 10% of your purchases, too

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goldfish_brain

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lagomorphlecture

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goldfndr

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Why are space shuttles always rockets, and take off straight upward?

So spaceplanes are a thing https://en.wikipedia.org/wiki/Spaceplane But they do take off vertically. From my experiemce with kerbal space program, it’s because of the density of the atmosphere. The closer to sea level, the denser the atmosphere and the more drag from air resistance. So instead of burning a ton of fuel trying to get through the thick atmosphere, you go straight up until it’s thinner and then you start to turn. Makes a huge difference. There’s also the fact that bigger rockets with more fuel create more drag so the solution isn’t “just make it bigger”

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GonzoVeritas

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Switzerland to vote on plan to cap population at 10 million

There are legitimate complaints from the anti-immigration camp, resources reaching their limits and dwindling government support are real problems. I don’t see this as a factor of immigration, but rather the endgame of a system that feeds on more. In the case of the UK, virtually every ‘anti-immigration’ Conservative government actually increased immigration more than the Labour opposition. I suppose no one knows the ‘benefits’ of cheap labour and infinite growth better. My feeling is, until a balanced steady-state economic system is acheived, or even desired, immigration will remain a side-show. The proposed Swiss law says it all. When the population reaches 9.5 million, the government must ‘do something’. Good luck.

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mangosloth

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AIPAC Wants Democrats to Back Israel. Instead, They’re Turning on AIPAC.

cross-posted from: https://lemmy.ml/post/48650874 Once the guardian of the bipartisan pro-Israel consensus, it is now a polarizing force in the party. June 12, 2026, 5:01 a.m. ET When Brad Lander opened his Democratic primary bid for New York’s 10th Congressional District late last year, he made a promise that would once have meant political suicide: He would not do “AIPAC’s bidding” in Washington. Now the June 23 primary is almost here, and AIPAC has been a recurring theme throughout the campaign. A progressive Jew and self-described liberal Zionist, Lander challenged his opponent, the pro-Israel incumbent Dan Goldman, to take a “people’s pledge” to limit money from super PACs. He has sent a steady stream of text and email blasts comparing AIPAC with Wall Street and crypto — a new, unholy trinity of corrupting influences in democratic politics.